Schaetti D, Blumer D, Dutar N, Gaudenz R, Hugentobler W
Gebh.-Gyn. Klinik, Kantonsspital Liestal.
Geburtshilfe Frauenheilkd. 1991 Jan;51(1):23-6. doi: 10.1055/s-2008-1026326.
In a prospective study, 121 patients with spontaneous rupture of the membranes of greater than 6 hours duration and unfavourable Bishop-Score (less than 6) were stimulated with 3 mg vaginal prostaglandin-E2-tablets. All patients started labour. Only one patient had a hyperstimulation which was corrected with betamimetics. There were no systemic side effects. Almost 90% of the women delivered on the first day. The rate of the Caesarean sections was low. There was no case of intraamniotic infection; the foetal outcome was good. In conclusion, vaginal prostaglandin-E2-tablets are safe to use in spontaneous rupture of the membranes.
在一项前瞻性研究中，对121例胎膜自然破裂超过6小时且Bishop评分不佳（小于6分）的患者，使用3毫克阴道用前列腺素E2片进行引产。所有患者均开始分娩。只有1例患者出现子宫收缩过强，使用β-拟交感神经药后得到纠正。未出现全身性副作用。近90%的女性在第一天分娩。剖宫产率较低。没有发生羊膜腔内感染的病例；胎儿结局良好。总之，阴道用前列腺素E2片用于胎膜自然破裂时使用安全。
