Okamoto M, Sasano M, Goto M, Nishioka K, Aotsuka S, Nakamura K, Yokohari R
Institute of Rheumatology, Tokyo Women's Medical College, Japan.
Int J Immunopharmacol. 1991;13(1):39-43. doi: 10.1016/0192-0561(91)90023-z.
We developed an ELISA system for human IL-1 alpha and -beta release from silica-stimulated monocytes from healthy volunteers and tested the effect of several anti-rheumatic drugs including nonsteroidal anti-inflammatory drug (Ibuprofen). Anti-rheumatic drugs including Auranofin and Sulphasalazine suppressed IL-1 beta release significantly at therapeutic concentrations, whereas Bucillamine, Lobenzarit, D-Penicillamine and Ibuprofen did not. These results suggest a possible immunotherapeutic effectiveness of some anti-rheumatic drugs on rheumatoid arthritis through their inhibition of IL-1 beta release.
我们开发了一种酶联免疫吸附测定（ELISA）系统，用于检测健康志愿者的二氧化硅刺激单核细胞释放人白细胞介素-1α（IL-1α）和白细胞介素-1β（IL-1β），并测试了几种抗风湿药物的效果，包括非甾体抗炎药（布洛芬）。金诺芬和柳氮磺胺吡啶等抗风湿药物在治疗浓度下可显著抑制IL-1β的释放，而青霉胺、氯苯柳胺、D-青霉胺和布洛芬则无此作用。这些结果表明，一些抗风湿药物通过抑制IL-1β的释放，可能对类风湿性关节炎具有免疫治疗效果。
