Kubota K, Takahashi T, Fujiwara T, Yamada S, Sato T, Kubota R, Iwata R, Ishiwata K, Ido T, Matsuzawa T
Départment of Radiology and Nuclear Medicine, Tohoku University, Sendai, Japan.
Int J Rad Appl Instrum B. 1991;18(2):191-5. doi: 10.1016/0883-2897(91)90078-y.
Newly synthesized 17-[18F]fluoro-3-methylheptadecanoic acid ([18F]BMHDA), 16-[18F]fluoropalmitic acid ([18F]PA) and 15-(p-[125I]iodophenyl)-3-R,S-methylpentadecanoic acid ([125I]BMIPP), fatty acid tracers, were examined for the possibility of tumor imaging using 10 tumor models in rats and mice. The highest tumor/muscle ratios with [18F]BMHDA were 2.3 using rat tumor AH109A and 1.9 using mouse tumor B16F1 (tumor accumulation 0.41 +/- 0.05, 4.29 +/- 0.77% ID/g, respectively). Tumor/muscle ratios with [125I]BMIPP and [18F]PA were lower than those with [18F]BMHDA. Labeled fatty acids seem to have a lower potential for tumor detection.
