Fulton R B, Fruechte L K
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
J Am Vet Med Assoc. 1991 Mar 1;198(5):883-5.
Signs of depression, hyperphosphatemia, azotemia, high anion gap metabolic acidosis, and renal failure developed in an adult cat following administration of an excessive dose of a phosphate-containing urinary acidifier. After extracellular fluid volume expansion, diuresis, and administration of a phosphate binder, serum phosphorus concentration returned to normal in 12 hours; the cat recovered fully. The urinary acidifier had been given as part of treatment for a urinary tract infection. Findings suggest that phosphate-containing urinary acidifiers should be administered cautiously because, like other sources of phosphate, they are capable of causing life-threatening metabolic disturbances.
一只成年猫在过量服用含磷酸盐的尿酸化剂后出现了抑郁、高磷血症、氮质血症、高阴离子间隙代谢性酸中毒和肾衰竭的症状。在细胞外液量扩充、利尿并给予磷酸盐结合剂后，血清磷浓度在12小时内恢复正常；这只猫完全康复。该尿酸化剂是作为尿路感染治疗的一部分给予的。研究结果表明，含磷酸盐的尿酸化剂应谨慎使用，因为与其他磷源一样，它们能够引起危及生命的代谢紊乱。
