Atkins C E, Tyler R, Greenlee P
Am J Vet Res. 1985 Apr;46(4):980-8.
Ten clinically healthy cats were allotted into 2 groups. Group A was given the low (60 ml), and group B was given the high (120 ml) recommended dose of a commercial hypertonic sodium phosphate enema. Enema retention was enforced. All cats developed clinical and/or laboratory abnormalities, with group B cats being more severely affected. Clinical signs that occurred rapidly included depression, ataxia, vomition, bloody diarrhea, mucous membrane pallor, and stupor; tetany was not seen. One cat in group B died. Laboratory abnormalities included hypernatremia, hyperphosphatemia, hypocalcemia, hyperglycemia, calculated hyperosmolality, and metabolic acidosis with high anion gap probably due to hyperlacticacidemia. There were no significant gross or microscopic lesions associated with enema administration. Therefore, the use of hypertonic sodium phosphate enema at recommended doses is potentially dangerous to cats.
十只临床健康的猫被分为两组。A组给予低剂量（60毫升），B组给予高剂量（120毫升）的市售高渗磷酸钠灌肠剂推荐剂量。强制保留灌肠剂。所有猫都出现了临床和/或实验室异常，B组猫受影响更严重。迅速出现的临床症状包括抑郁、共济失调、呕吐、血便、黏膜苍白和昏迷；未见手足搐搦。B组有一只猫死亡。实验室异常包括高钠血症、高磷血症、低钙血症、高血糖、计算得出的高渗状态以及可能由于高乳酸血症导致的高阴离子间隙代谢性酸中毒。灌肠给药未发现明显的大体或微观病变。因此，按推荐剂量使用高渗磷酸钠灌肠剂对猫有潜在危险。
