臭氧与生物分子反应产生单线态氧。

Singlet oxygen production from the reactions of ozone with biological molecules.

作者信息

Kanofsky J R, Sima P

机构信息

Medical Service, Edward Hines, Jr. Department of Veterans Affairs Hospital, Hines, Illinois 60141.

出版信息

J Biol Chem. 1991 May 15;266(14):9039-42.

PMID:2026612

Abstract

The reaction of ozone with a number of biological molecules was found to produce singlet oxygen in high yield. At pH 7.0, the reaction of ozone with an equimolar amount of biological molecule produced the following singlet oxygen yields (mole of singlet oxygen/mole of ozone): cysteine, 0.49 +/- 0.02; methionine, 1.13 +/- 0.11; reduced glutathione, 0.33 +/- 0.02; albumin, 1.00 +/- 0.05; uric acid, 0.64 +/- 0.09; ascorbic acid, 0.96 +/- 0.007; NADPH, 1.07 +/- 0.07; NADH, 0.95 +/- 0.01. Thus, singlet oxygen may be an important intermediate in the biochemical damage caused by ozone.

摘要

人们发现，臭氧与多种生物分子发生反应时会高产率地生成单线态氧。在pH 7.0的条件下，臭氧与等摩尔量的生物分子发生反应，产生的单线态氧产率如下（单线态氧的摩尔数/臭氧的摩尔数）：半胱氨酸，0.49±0.02；蛋氨酸，1.13±0.11；还原型谷胱甘肽，0.33±0.02；白蛋白，1.00±0.05；尿酸，0.64±0.09；抗坏血酸，0.96±0.007；烟酰胺腺嘌呤二核苷酸磷酸（NADPH），1.07±0.07；烟酰胺腺嘌呤二核苷酸（NADH），0.95±0.01。因此，单线态氧可能是臭氧造成生化损伤过程中的一种重要中间体。