Joyce P R
University Department of Psychological Medicine, Christchurch School of Medicine, New Zealand.
J Psychiatr Res. 1991;25(1-2):1-6. doi: 10.1016/0022-3956(91)90011-x.
Free thyroxine index (FT4I) and thyroxine (T4) levels were measured in 31 manic patients shortly after admission to a psychiatric hospital. Over one-third had elevated thyroid hormone levels, and this was largely due to increases in FT4I. Increased FT4I levels were associated with greater sleep disturbance and with being male, and were negatively associated with having had hospital admissions in the past six months. More interestingly, however, low FT4I levels prospectively predicted more hospital admissions in the 12 months from index admission, and this was not due to past admissions predicting future admissions. This adds to the growing literature on important relationships between thyroid hormones and treatment outcome in patients with affective disorders.
在31名躁狂症患者入院后不久，测量了他们的游离甲状腺素指数（FT4I）和甲状腺素（T4）水平。超过三分之一的患者甲状腺激素水平升高，这在很大程度上是由于FT4I升高所致。FT4I水平升高与更严重的睡眠障碍以及男性性别相关，并且与过去六个月内的住院次数呈负相关。然而，更有趣的是，低FT4I水平前瞻性地预测了自索引入院起12个月内更多的住院次数，这并非是由于过去的住院次数预测未来的住院次数。这为关于甲状腺激素与情感障碍患者治疗结果之间重要关系的不断增长的文献增添了内容。
