Kuettner K E, Aydelotte M B, Thonar E J
Department of Biochemistry, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, IL 60612-3864.
J Rheumatol Suppl. 1991 Feb;27:46-8.
The ability of articular cartilage to undergo reversible deformation is dependent upon the organization of specific macromolecules within the extracellular matrix. This abundant matrix is elaborated by a small number of chondrocytes which maintain homeostasis via a synchronized balance between anabolism and catabolism. Type II collagen together with smaller amounts of other collagens form the fibrous network of the tissue in which are "entrapped" the aggregating proteoglycans in an underhydrated form. Small amounts of nonaggregating dermatan sulfate containing proteoglycans and matrix proteins are also present in the matrix but their function is less well understood.
关节软骨进行可逆变形的能力取决于细胞外基质中特定大分子的组织形式。这种丰富的基质由少数软骨细胞产生，这些软骨细胞通过合成代谢和分解代谢之间的同步平衡来维持体内稳态。II型胶原蛋白与少量其他胶原蛋白一起构成了组织的纤维网络，聚集蛋白聚糖以水合不足的形式“被困”在其中。基质中还存在少量含硫酸皮肤素的非聚集蛋白聚糖和基质蛋白，但其功能尚不太清楚。
