血液系统恶性肿瘤患者的金黄色葡萄球菌败血症：耐甲氧西林金黄色葡萄球菌败血症增加

[Staphylococcus aureus sepsis in patients with hematological malignancies: increase in MRSA sepsis].

作者信息

Itoh M, Yoshida M, Kurata H, Imagawa S, Hoshino M, Tsunoda J, Ema H, Tsunoda S, Suzuki T, Komatsu N

机构信息

Department of Medicine, Jichi Medical School.

出版信息

Rinsho Ketsueki. 1991 Feb;32(2):115-20.

PMID:2027237

Abstract

From January 1978 to August 1990, Staphylococcus aureus bacteremia (SAB) were identified in 31 patients with hematological malignancies at Jichi Medical School hospital. Mortality due to SAB was 48.4% (15/31). Of the variables analyzed, four factors were significantly associated with a poor prognosis; elderly age (p = 0.015), high granulocyte count (more than 500/microliters) (p = 0.015), presence of DIC (p = 0.011) and presence of pneumonia (p = 0.023). The incidence of methicillin-resistant SAB was 32.3% (10/31) and the first patient developed in 1985. Although not statistically significant, there was a trend of higher mortality for methicillin-resistant SAB (70%) than for methicillin-sensitive SAB (38.1%). Most strains of methicillin-resistant Staphylococcus aureus were sensitive to minocycline, chloramphenicol and vancomycin.

摘要

1978年1月至1990年8月，在秩父医科大学医院确诊31例血液系统恶性肿瘤患者发生金黄色葡萄球菌菌血症（SAB）。SAB导致的死亡率为48.4%（15/31）。在分析的变量中，有四个因素与预后不良显著相关；高龄（p = 0.015）、高粒细胞计数（超过500/微升）（p = 0.015）、存在弥散性血管内凝血（DIC）（p = 0.011）和存在肺炎（p = 0.023）。耐甲氧西林SAB的发生率为32.3%（10/31），首例患者于1985年出现。尽管无统计学意义，但耐甲氧西林SAB的死亡率（70%）有高于甲氧西林敏感SAB（38.1%）的趋势。大多数耐甲氧西林金黄色葡萄球菌菌株对米诺环素、氯霉素和万古霉素敏感。