Itoh M, Yoshida M, Kurata H, Imagawa S, Hoshino M, Tsunoda J, Ema H, Tsunoda S, Suzuki T, Komatsu N
Department of Medicine, Jichi Medical School.
Rinsho Ketsueki. 1991 Feb;32(2):115-20.
From January 1978 to August 1990, Staphylococcus aureus bacteremia (SAB) were identified in 31 patients with hematological malignancies at Jichi Medical School hospital. Mortality due to SAB was 48.4% (15/31). Of the variables analyzed, four factors were significantly associated with a poor prognosis; elderly age (p = 0.015), high granulocyte count (more than 500/microliters) (p = 0.015), presence of DIC (p = 0.011) and presence of pneumonia (p = 0.023). The incidence of methicillin-resistant SAB was 32.3% (10/31) and the first patient developed in 1985. Although not statistically significant, there was a trend of higher mortality for methicillin-resistant SAB (70%) than for methicillin-sensitive SAB (38.1%). Most strains of methicillin-resistant Staphylococcus aureus were sensitive to minocycline, chloramphenicol and vancomycin.
1978年1月至1990年8月，在秩父医科大学医院确诊31例血液系统恶性肿瘤患者发生金黄色葡萄球菌菌血症（SAB）。SAB导致的死亡率为48.4%（15/31）。在分析的变量中，有四个因素与预后不良显著相关；高龄（p = 0.015）、高粒细胞计数（超过500/微升）（p = 0.015）、存在弥散性血管内凝血（DIC）（p = 0.011）和存在肺炎（p = 0.023）。耐甲氧西林SAB的发生率为32.3%（10/31），首例患者于1985年出现。尽管无统计学意义，但耐甲氧西林SAB的死亡率（70%）有高于甲氧西林敏感SAB（38.1%）的趋势。大多数耐甲氧西林金黄色葡萄球菌菌株对米诺环素、氯霉素和万古霉素敏感。
