Fagan S C, Nacci N
College of Pharmacy, Wayne State University, Detroit, MI.
DICP. 1991 Mar;25(3):247-9. doi: 10.1177/106002809102500305.
A patient who had suffered an acute ischemic stroke experienced bradycardia while being treated with nimodipine 80 mg tid. This became evident after the initiation of nimodipine and progressed, leading to the drug being discontinued after three days of therapy. The bradycardia resolved shortly after the treatment was terminated and normal heart rate was maintained throughout 23 days of hospitalization and in subsequent outpatient follow-up. Although nimodipine-induced bradycardia is possible, hemispheric cerebral infarction may also cause transient bradyarrhythmias in the acute stroke period. There is a need to monitor the heart rate and rhythm of all acute stroke patients, especially those receiving nimodipine.
一名急性缺血性中风患者在接受尼莫地平80毫克每日三次治疗时出现心动过缓。这在开始使用尼莫地平后变得明显，并逐渐加重，导致治疗三天后停药。治疗终止后不久心动过缓消失，在整个住院23天期间及随后的门诊随访中均维持正常心率。虽然尼莫地平可能导致心动过缓，但半球性脑梗死在急性中风期也可能引起短暂性心律失常。有必要监测所有急性中风患者的心率和心律，尤其是那些正在接受尼莫地平治疗的患者。
