Szczechowski L, Wajgt A
I Katedry i Kliniki Neurologii Sl. AM., Katowicach.
Neurol Neurochir Pol. 1994 May-Jun;28(3):299-306.
The authors present the results of treating acute hemispheric stroke with intravenous nimodipine. 17 patients were additionally treated with nimodipine given intravenously in 1 mg-2 mg dose, and the control group consisted of 71 patients treated in standard way with Dextran 40,000. The selection of patients for the study was random, and the treatment was conducted by blind trial method. All patients were admitted within 24 hours since acute stroke onset. The diagnosis was based on clinical examination and CT. The analysis of treatment results was made twice before and after the treatment according to criteria recommended by WHO Karnofsky scale. Statistical analysis showed that in the group treated additionally with nimodipine neurological and social consequences of stroke were significantly lower in comparison with standard therapy (p < 0.001).
作者介绍了静脉注射尼莫地平治疗急性半球性卒中的结果。17例患者额外接受了静脉注射尼莫地平治疗，剂量为1毫克至2毫克，对照组由71例采用标准方法用低分子右旋糖酐40000治疗的患者组成。研究患者的选择是随机的，治疗采用盲法试验。所有患者在急性卒中发作后24小时内入院。诊断基于临床检查和CT。根据世界卫生组织卡诺夫斯基量表推荐的标准，在治疗前后对治疗结果进行了两次分析。统计分析表明，与标准治疗相比，额外接受尼莫地平治疗的组中卒中的神经和社会后果显著更低（p<0.001）。
