人类肝脏中年龄与阿司匹林酯酶活性的关联。
The association of age with aspirin esterase activity in human liver.
作者信息
Yelland C, Summerbell J, Nicholson E, Herd B, Wynne H, Woodhouse K W
机构信息
Department of Medicine (Geriatrics), The University, Newcastle upon Tyne.
出版信息
Age Ageing. 1991 Jan;20(1):16-8. doi: 10.1093/ageing/20.1.16.
PMID:2028845
Abstract
The activity of the phase 1 enzyme aspirin esterase was studied in liver tissue from 16 patients, aged 45-88 years. No correlation between age and enzyme activity was found in post-mitochondrial, cytosolic and microsomal fractions. These results provide further evidence that age is not a major determinant of the activity of hepatic drug-metabolizing enzymes in man.
摘要
对16名年龄在45至88岁之间患者的肝脏组织中1期酶阿司匹林酯酶的活性进行了研究。在线粒体后、胞质和微粒体组分中未发现年龄与酶活性之间存在相关性。这些结果进一步证明，年龄不是人类肝脏药物代谢酶活性的主要决定因素。
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