Human liver and plasma aspirin esterase.
作者信息
Williams F M, Mutch E M, Nicholson E, Wynne H, Wright P, Lambert D, Rawlins M D
机构信息
Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne, UK.
出版信息
J Pharm Pharmacol. 1989 Jun;41(6):407-9. doi: 10.1111/j.2042-7158.1989.tb06487.x.
Abstract
The plasma, in addition to the liver, is a major site of hydrolysis of aspirin. Human plasma and liver aspirin esterase activities in samples from a group of patients varied over a two fold range and there was a significant correlation between individual plasma and liver activities. Human liver aspirin esterase was present in the cytosolic and microsomal fractions. Cytosolic and microsomal enzymes had different activities and apparent affinities for aspirin.
摘要
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