Heng M C, Allen S G, Song M K, Heng M K
Division of Dermatology, Veterans Administration Medical Center, Sepulveda, CA 91343.
Am J Dermatopathol. 1991 Apr;13(2):108-14. doi: 10.1097/00000372-199104000-00002.
Microangiopathy is an essential component in diabetic vascular pathology. We report ultrastructural observations of ballooning degeneration involving isolated endothelial cells of cutaneous capillaries, while leaving adjacent endothelial cells relatively intact in six diabetic patients with early lesions of necrobiosis lipoidica induced by trauma. Focal proliferation of endothelial cells encroaching upon the vascular lumina (obliterative endarteritis) was also observed. Lectin studies on biopsy specimens of older lesions of necrobiosis lipoidica revealed paucity of dermal blood vessels. These observations enable us to gain further insight into the pathophysiological mechanisms that underlie diabetic microvascular disease.
微血管病变是糖尿病血管病变的重要组成部分。我们报告了6例因创伤诱发早期类脂质渐进性坏死病变的糖尿病患者皮肤毛细血管单个内皮细胞气球样变性的超微结构观察结果，而相邻的内皮细胞相对完整。还观察到内皮细胞局灶性增生并侵入血管腔（闭塞性动脉内膜炎）。对类脂质渐进性坏死较陈旧病变活检标本的凝集素研究显示真皮血管稀少。这些观察结果使我们能够进一步深入了解糖尿病微血管疾病的病理生理机制。
