Chan H L
Department of Medicine, National University Hospital, Singapore.
Ann Acad Med Singap. 1991 Jan;20(1):133-8.
Topical corticosteroids are widely used on the human skin. The activity of corticosteroids are influenced by their molecular structure. Their action is believed to be mediated through binding to specific glucocorticosteroid receptors in the cytoplasm of cells. The beneficial clinical effects topical corticosteroids are due mainly to its anti-inflammatory property. Percutaneous absorption of topical corticosteroids is affected by variables relating to: (a) the steroid molecular itself, (b) the vehicle in which the ingredient is incorporated and, (c) the skin itself. All these factors must be taken into account in the evaluation of their activity. The more potent the topical corticosteroid, the greater the propensity to cause unwanted effects. Many adverse effects have been reported. Physicians should learn to use these drugs judiciously so as to maximise their desired effects and to minimise their undesired effects.
局部用皮质类固醇广泛应用于人体皮肤。皮质类固醇的活性受其分子结构影响。据信它们的作用是通过与细胞胞质中的特定糖皮质激素受体结合来介导的。局部用皮质类固醇有益的临床效果主要归因于其抗炎特性。局部用皮质类固醇的经皮吸收受以下相关变量影响：(a)类固醇分子本身，(b)药物成分所包含的载体，以及(c)皮肤本身。在评估它们的活性时必须考虑所有这些因素。局部用皮质类固醇越强效，引起不良反应的倾向就越大。已经报道了许多不良反应。医生应学会明智地使用这些药物，以最大限度地发挥其预期效果并最小化其不良效果。
