Ho H N, Gill T J, Hsieh H J, Jiang J J, Lee T Y, Hsieh C Y
Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Republic of China.
Am J Reprod Immunol. 1991 Jan;25(1):10-5. doi: 10.1111/j.1600-0897.1991.tb01056.x.
The efficacy of immunotherapy for the treatment of recurrent spontaneous abortions was tested in patients selected from the same ethnically homogeneous population of Chinese in Taiwan in whom the immunogenetics of gestational trophoblastic tumors and of recurrent spontaneous abortion had been studied. The patients, who included both primary and secondary aborters, were randomly assigned to three groups: those who were immunized with their own lymphocytes (controls) (49); those who were immunized with their husbands' lymphocytes (39); and those who were immunized with third party lymphocytes (11). The data were analyzed individually for the primary and secondary aborters and collectively for both groups combined. The number of babies born, the number of current pregnancies, and the number of recurrent abortions were not statistically significantly different between the control and the immunized groups, and a similar small number of congenital abnormalities (4-9%) occurred in both the control and immunized groups. The increase in the blocking effect for the mixed lymphocyte reaction was not related to the success of the postimmunization pregnancies. Thus, this study does not show any significant improvement in the rate of livebirths in women immunized with their husbands' lymphocytes or with third party lymphocytes compared to that in a placebo-controlled group of women.
在台湾同一民族的华裔人群中，对复发性自然流产患者进行免疫治疗的疗效进行了测试，该人群中已对妊娠滋养细胞肿瘤和复发性自然流产的免疫遗传学进行了研究。患者包括原发性和继发性流产者，被随机分为三组：用自身淋巴细胞免疫的患者（对照组）（49例）；用丈夫淋巴细胞免疫的患者（39例）；用第三方淋巴细胞免疫的患者（11例）。分别对原发性和继发性流产者的数据进行分析，并对两组合并的数据进行总体分析。对照组和免疫组之间出生婴儿的数量、当前怀孕的数量和复发性流产的数量在统计学上没有显著差异，对照组和免疫组中出现先天性异常的比例相似（4-9%）。混合淋巴细胞反应阻断效应的增加与免疫后妊娠的成功无关。因此，与安慰剂对照组的女性相比，本研究未显示用丈夫淋巴细胞或第三方淋巴细胞免疫的女性活产率有任何显著提高。
