Norlén B J
Department of Urology, University Hospital, Uppsala, Sweden.
Acta Oncol. 1991;30(2):141-4. doi: 10.3109/02841869109092337.
A total of 44,300 cases of prostatic cancer, comprising 99% of all newly diagnosed living cases reported to the Swedish Cancer Registry in 1960 through 1978 constituted a cohort followed up for 1-19 years. Survival rates were adjusted for expected mortality in the general population and were expressed as relative survival (RS). RS for the total cohort after 5, 10 and 20 years was 51, 34 and 17% respectively, with an annual excess death rate of about 8% which persisted also after long-term observation. RS was similar in age groups between 45 and 74 years, whereas among patients older than 74 years at diagnosis approximately 10% lower RS appeared early and was persistent. RS improved for patients diagnosed at consecutive 5-year periods. Thus, the high mortality rate in old age groups and the low long-term RS contradicted the concept that biologically inactive tumours constitute a significant proportion of prostatic cancers diagnosed in clinical practice.
1960年至1978年期间，瑞典癌症登记处报告的44300例前列腺癌病例占所有新诊断存活病例的99%，这些病例构成了一个随访1至19年的队列。根据一般人群的预期死亡率对生存率进行了调整，并以相对生存率（RS）表示。整个队列5年、10年和20年后的相对生存率分别为51%、34%和17%，年超额死亡率约为8%，长期观察后仍持续存在。45至74岁年龄组的相对生存率相似，而诊断时年龄超过74岁的患者相对生存率早期约低10%且持续存在。连续5年诊断的患者相对生存率有所提高。因此，老年组的高死亡率和低长期相对生存率与生物学上不活跃的肿瘤在临床实践中诊断的前列腺癌中占很大比例这一概念相矛盾。
