Grönberg H, Damber L, Jonson H, Damber J E
Department of Oncology, Umeå University, Sweden.
Urology. 1997 Mar;49(3):374-8. doi: 10.1016/S0090-4295(96)00508-0.
This study is designed to estimate the prostate cancer-specific mortality according to patient age and tumor grade in an unselected population of patients with prostate cancer who mostly received deferred or direct hormonal treatment as initial treatment.
The study population was composed of 6514 patients diagnosed with prostate cancer during 1971 to 1987 in northern Sweden. For those who died during follow-up, the cause of death was determined from the comprehensive Swedish registry data (population registries and causes of death registry).
About 85% of these patients died during the 7 to 23 years of follow-up, and the prostate cancer-specific mortality was estimated to be 55%. Age at diagnosis was found to be a strong predictor of prostate cancer death. Patients diagnosed before the age of 60 had an 80% risk of dying of prostate cancer, whereas those over 80 years of age at diagnosis had less than a 50% risk of prostate cancer-related death.
The prostate cancer mortality is high but decreases with older age at diagnosis. We found, using data from the causes of death registry, that the relative survival and the cause-specific survival of these patients were compatible with each other.
本研究旨在估计在未经过挑选、大多接受延迟或直接激素治疗作为初始治疗的前列腺癌患者群体中，根据患者年龄和肿瘤分级的前列腺癌特异性死亡率。
研究人群由1971年至1987年期间在瑞典北部被诊断为前列腺癌的6514名患者组成。对于随访期间死亡的患者，从瑞典综合登记数据（人口登记和死亡原因登记）中确定死亡原因。
在7至23年的随访期间，约85%的这些患者死亡，前列腺癌特异性死亡率估计为55%。诊断时的年龄被发现是前列腺癌死亡的有力预测因素。60岁之前被诊断出的患者有80%死于前列腺癌的风险，而诊断时年龄超过80岁的患者与前列腺癌相关的死亡风险不到50%。
前列腺癌死亡率很高，但随着诊断时年龄的增长而降低。我们利用死亡原因登记数据发现，这些患者的相对生存率和特定病因生存率相互吻合。
