[Comparative studies on cytokinesis-block and conventional micronucleus test in human lymphocyte cultured in vitro. I. Effects of medium and low doses of gamma-rays].

In this paper the authors have studied relationship between gamma-ray dose and mean MNCF measured separately by Cytokinesis-block and conventional micronucleus test (BC- and C-MNT) to increase the sensitivity of MNT in human lymphocyte and to explore the possibility of using MNT in human lymphocyte as biodosimetry. The main results show that using C-MNT low dose of gamma-rays (0.1, 0.3 GYs) could increase mean MNCF as compared with control; but using BC-MNT mean MNCF could not be increased. With medium dose of gamma-rays (0.7-3.1 GYs) mean MNCF measured by BC-MNT is more significant than that measured by C-MNCT.