Czekalski S, Baczyk K
Proc Eur Dial Transplant Assoc. 1977;14:451-60.
The purpose of the study was the evaluation of nephrogenous adenosine 3'5' monophosphate (ncAMP) determinations in the diagnosis of hyperparathyroidism (HPT) in chronic renal disease (CRD). The ratio of cAMP clearance to creatinine clearance (CcAMP/Ccr) was applied as the index of the participation of ncAMP in 24 hr urinary cAMP excretion. In seventy CRD patients, the mean CcAMP/Ccr value was higher than in healthy individuals. A good correlation between plasma iPTH and CcAMP/Ccr ratio was noted. In patients with a ratio higher than 2.5, the signs of HPT were found. The determination of CcAMP/Ccr ratio in CRD may be of value in the assessment of parathyroid hyperactivity.
本研究的目的是评估肾源性3',5'-环磷酸腺苷（ncAMP）测定在慢性肾病（CRD）患者甲状旁腺功能亢进症（HPT）诊断中的作用。以环磷酸腺苷清除率与肌酐清除率的比值（CcAMP/Ccr）作为ncAMP参与24小时尿中环磷酸腺苷排泄的指标。70例CRD患者的平均CcAMP/Ccr值高于健康个体。血浆iPTH与CcAMP/Ccr比值之间存在良好的相关性。在比值高于2.5的患者中，发现了HPT的体征。测定CRD患者的CcAMP/Ccr比值可能对评估甲状旁腺功能亢进有价值。
