Holter P H, Framstad T, Aulie A, Refsum H E, Sjaastad O V
Laboratory for Clinical Physiology, Ullevål Hospital, Oslo, Norway.
Pediatr Hematol Oncol. 1991 Jan-Mar;8(1):1-11. doi: 10.3109/08880019109033422.
The development of postnatal anemia and the preventive and curative effect of iron supplementation were examined in 34 piglets from three litters of Norwegian Landrace pigs. A prostaglandin analog was given on day 111 or 112 of pregnancy, and the piglets were removed by caesarean section. Seventeen piglets were given 180 mg iron as colloidal ferridextran subcutaneously at birth (0 = day group); the remaining 17 were given the same amount on day 13 (13-day group). The piglets had access to a milk substitute from day 1 to day 7 and pelleted food for piglets after day 13. From about 4 weeks of age the piglets ate considerable amounts of pellets. The red blood cell count (RBC) and hemoglobin concentration (Hb) at birth were 3.2 +/- 0.4 (SD) x 10(12)/L and 80.4 +/- 8.1 x 10(12) g/L, respectively. In both groups Hb, RBC, mean corpuscular volume (MCV), and particularly packed cell volume (PCV) decreased markedly the first day after birth. In the 13-day group there was a further decrease until treatment with iron on day 13. Injection with iron on day 13 led to a rapid increase in the above mentioned parameters, with statistically significant increases for Hb, PCV, and MCV four days after treatment. The calculated mass of hemoglobin was fairly constant until treatment in the 13-day group. In the group given iron at birth the data obtained indicate that the amount of iron given is insufficient to sustain a production of normal-sized erythrocytes with a normal mean corpuscular hemoglobin concentration for more than approximately 21 days. Furthermore, the present study also indicates that MCV is a sensitive indicator of iron availability in piglets.
对来自三窝挪威长白猪的34头仔猪进行了产后贫血的发展情况以及铁补充剂的预防和治疗效果研究。在妊娠第111天或112天给予前列腺素类似物，然后通过剖腹产取出仔猪。17头仔猪在出生时皮下注射180毫克胶体铁右旋糖酐（0日龄组）；其余17头在第13天注射相同剂量（13日龄组）。仔猪从第1天到第7天可食用代乳品，13天后可食用仔猪颗粒饲料。从大约4周龄开始，仔猪大量食用颗粒饲料。出生时红细胞计数（RBC）和血红蛋白浓度（Hb）分别为3.2±0.4（标准差）×10¹²/L和80.4±8.1×10¹²g/L。两组仔猪出生后第一天Hb、RBC、平均红细胞体积（MCV），尤其是红细胞压积（PCV）均显著下降。在13日龄组，直到第13天进行铁治疗前，这些指标进一步下降。第13天注射铁后，上述参数迅速增加，治疗后4天Hb、PCV和MCV有统计学意义的升高。在13日龄组治疗前，计算得出的血红蛋白量相当恒定。在出生时给予铁的组中，所获得的数据表明，给予的铁量不足以维持正常大小红细胞的生成以及正常的平均红细胞血红蛋白浓度超过约21天。此外，本研究还表明，MCV是仔猪铁供应情况的敏感指标。
