Holter P H, Refsum H E
Laboratory for Clinical Physiology, Ullevaal Hospital, Oslo, Norway.
Pediatr Hematol Oncol. 1988;5(3):157-68. doi: 10.3109/08880018809031266.
Two groups of suckling rabbits were studied from the 15th to the 40th day after birth, one group receiving mothers milk only, the other having the choice of iron-containing food pellets from the 20th day. In the milk-only group, the plasma iron concentration (P-Fe), blood hemoglobin concentration (B-Hb), red blood cell count (B-RBC), and mean corpuscular volume (MCV) declined continuously, whereas the hemoglobin mass of the blood (Hb-mass) remained unchanged, and the blood platelet count (B-PLTS), plasma platelet count (P-PLTS), and the estimated platelet release to the blood (PLT-release) showed a continuous rise. The milk-pellet group showed the same pattern until the 25th-30th day; thereafter, P-Fe, B-Hb, and Hb-mass rose markedly, whereas B-PLTS and PLT-release declined. At the time of weaning, both groups showed bimodal erythrocyte volume distribution curves. Thereafter, the milk-only group developed a pure microcytemia, whereas the milk-pellet group got normovolemic erythrocytes only. In conclusion, the erythropoiesis in suckling rabbits is characterized by a balanced recycling of an essentially constant amount of available iron, preventing rise of Hb-mass. The anemia thus reflects a failure of the Hb-mass to keep up with the growth-related rise in plasma volume. A close relationship exists between postnatal iron deficient microcytic anemia and thrombocytosis.
对两组新生兔进行了研究，从出生后第15天至第40天，一组仅喂母乳，另一组从第20天起可选择含铁食物颗粒。仅喂母乳组中，血浆铁浓度（P-Fe）、血血红蛋白浓度（B-Hb）、红细胞计数（B-RBC）和平均红细胞体积（MCV）持续下降，而血液血红蛋白量（Hb-mass）保持不变，血小板计数（B-PLTS）、血浆血小板计数（P-PLTS）以及估计的血小板向血液中的释放量（PLT-release）持续上升。喂母乳加食物颗粒组在第25 - 30天前呈现相同模式；此后，P-Fe、B-Hb和Hb-mass显著上升，而B-PLTS和PLT-release下降。断奶时，两组均呈现双峰红细胞体积分布曲线。此后，仅喂母乳组出现单纯小细胞性贫血，而喂母乳加食物颗粒组仅出现正常血容量红细胞。总之，新生兔的红细胞生成特点是对基本恒定数量的可利用铁进行平衡再循环，防止Hb-mass升高。因此，贫血反映了Hb-mass未能跟上与生长相关的血浆容量增加。出生后缺铁性小细胞性贫血与血小板增多症之间存在密切关系。
