Crestani F, Seguy F, Dantzer R
Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U. 259, Université de Bordeaux II, France.
Brain Res. 1991 Mar 1;542(2):330-5. doi: 10.1016/0006-8993(91)91587-q.
To investigate the possible mediation by prostaglandins of changes in behaviour induced by peripheral injection of interleukin-1 (IL-1), two types of behavioural tests were chosen, social exploration in mice and schedule-controlled behaviour in rats. Mice treated with 1 and 2.5 micrograms recombinant human IL-1 beta showed a time- and dose-dependent decrease in exploration of a juvenile conspecific. This effect was completely blocked by pretreatment with 10 mg/kg indomethacin or 10 mg/kg piroxicam, but not with 50 mg/kg aspirin. The disruption of operant responding induced by 5 micrograms IL-1 in rats was also suppressed by pretreatment with 5 mg/kg indomethacin or 10 mg/kg piroxicam. These results indicate that prostaglandins mediate the behavioural effects of peripherally injected IL-1.
为研究前列腺素是否可能介导外周注射白细胞介素-1（IL-1）所引起的行为变化，选用了两种行为测试，即小鼠的社交探索和大鼠的程序控制行为。用1微克和2.5微克重组人IL-1β处理的小鼠对幼年同种个体的探索呈时间和剂量依赖性减少。用10毫克/千克吲哚美辛或10毫克/千克吡罗昔康预处理可完全阻断此效应，但50毫克/千克阿司匹林则无此作用。用5毫克/千克吲哚美辛或10毫克/千克吡罗昔康预处理也可抑制5微克IL-1诱导的大鼠操作性反应中断。这些结果表明，前列腺素介导外周注射IL-1的行为效应。
