Claeyssens S, Lavoinne A, Daragon A, Josse S, Godin M, Matray F, Kuhn J M
Groupe de Biochimie et de Physiopathologie Digestive et Nutritionnelle, Hôpital Charles Nicolle, Rouen, France.
Clin Chim Acta. 1991 Jan 15;195(3):107-14. doi: 10.1016/0009-8981(91)90130-5.
Serum total, ultrafiltrable and protein-bound magnesium, and urinary fractional excretion of magnesium were studied in patients with primary hyperparathyroidism (before and after surgery) and in patients with hyperparathyroidism, malignant hypercalcemia and chronic renal failure with or without hemodialysis. Whereas serum total Mg was unchanged in patients with primary hyperparathyroidism, the ultrafiltrable magnesium concentration was higher than in the control group and higher before than after surgery. The total and the ultrafiltrable magnesium concentrations were highly correlated in the overall patients with Ca-related metabolic disorders, suggesting that renal function had no influence on the relation between these two parameters. Moreover, in malignant hypercalcemia, our results suggested that PTH-like peptides might be less effective than PTH in renal handling of Mg as previously described for Ca.
对原发性甲状旁腺功能亢进患者（手术前后）以及甲状旁腺功能亢进、恶性高钙血症和慢性肾衰竭患者（无论是否接受血液透析）的血清总镁、超滤镁、蛋白结合镁以及尿镁分数排泄进行了研究。原发性甲状旁腺功能亢进患者的血清总镁无变化，但超滤镁浓度高于对照组，且术前高于术后。在所有与钙相关的代谢紊乱患者中，总镁浓度和超滤镁浓度高度相关，提示肾功能对这两个参数之间的关系无影响。此外，在恶性高钙血症中，我们的结果表明，甲状旁腺激素样肽在肾脏处理镁方面可能不如甲状旁腺激素有效，正如之前所描述的在处理钙方面那样。
