Fargo Veterans Administration Medical Center, Fargo, ND 58102, USA.
Public Health Rep. 2010 Mar-Apr;125(2):246-9. doi: 10.1177/003335491012500213.
West Nile virus (WNV) continues to cause seasonal epidemics of neuroinvasive disease and febrile illness, which have been most dramatic in the central plains states. We studied the epidemiology of WNV disease in North Dakota (ND), a highly epidemic state, six years following its first appearance in the state.
We analyzed information from cases of WNV disease reported to the ND Department of Health during August 2002 through December 2007.
A total of 1246 cases of WNV disease were reported in ND; 183 cases experienced neuroinvasive disease, including meningitis, encephalitis, or acute flaccid paralysis. Risk factors associated with developing neuroinvasive disease rather than West Nile fever included older age, male gender, and residence in a rural area. Annual cumulative incidence of neuroinvasive disease in ND ranged from 0.3 per 100,000 population to 14.6 per 100,000 population.
Annual cumulative incidence rates of West Nile neuroinvasive disease suggest that this region offers favorable conditions for its continued enzootic transmission, which highlights the need for improved targeted prevention measures, particularly for rural areas of the state.
西尼罗河病毒（WNV）仍在导致神经侵袭性疾病和发热性疾病的季节性流行，在中部平原各州最为显著。我们研究了 WNV 疾病在北达科他州（ND）的流行情况，该州在首次出现 WNV 疾病后六年。
我们分析了 2002 年 8 月至 2007 年 12 月期间向 ND 卫生部报告的 WNV 疾病病例的信息。
ND 共报告了 1246 例 WNV 疾病病例；183 例发生神经侵袭性疾病，包括脑膜炎、脑炎或急性弛缓性麻痹。与发生西尼罗河热而非神经侵袭性疾病相关的危险因素包括年龄较大、男性和居住在农村地区。ND 每年神经侵袭性疾病的累积发病率从每 10 万人 0.3 例到每 10 万人 14.6 例不等。
WNV 神经侵袭性疾病的年累积发病率表明，该地区为其持续的地方性传播提供了有利条件，这突出表明需要改进有针对性的预防措施，特别是针对该州的农村地区。
