DHHC 蛋白家族的 S-酰化。
S-acylation by the DHHC protein family.
机构信息
Centre for Integrative Physiology, School of Biomedical Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
出版信息
Biochem Soc Trans. 2010 Apr;38(2):522-4. doi: 10.1042/BST0380522.
PMID:20298214
Abstract
A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.
摘要
现已鉴定出一个由 23 个 DHHC（天冬氨酸-组氨酸-组氨酸-半胱氨酸）蛋白组成的家族，这些蛋白作为哺乳动物 S-酰基转移酶发挥作用，这重新激发了对蛋白质 S-酰化的研究。最近的研究继续揭示了 S-酰化如何影响靶蛋白，并提供了 DHHC-底物特异性如何实现的一些线索。
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