关于“制定预防痴呆症的国家战略：2009 年利昂·塔尔研讨会”的述评。建立国家神经退行性疾病机构审查委员会的基本原理。

Commentary on "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." The rationale for a National Institutional Review Board for neurodegenerative diseases.

机构信息

Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.

出版信息

Alzheimers Dement. 2010 Mar;6(2):135-7. doi: 10.1016/j.jalz.2010.01.007.

DOI:10.1016/j.jalz.2010.01.007

PMID:20298974

Abstract

The published proceedings of the second Annual Leon Thal Symposium (Alzheimers Dement 2009;5:85-92) have added to the open discussion among leaders in this field, with respect to the development of a national strategy for accelerating the discovery of preventative interventions for Alzheimer's disease. One of the recommended "action steps" detailed in that report centers on the establishment of a National Institutional Review Board for neurodegenerative diseases. The purpose of this new ethical oversight panel would be to increase the efficiency with which large-scale multi-site trials are conducted. This essay expands on this recommendation, and two potential organizational models are briefly considered. A well-designed, highly-qualified, and responsive National Institutional Review Board for neurodegenerative diseases would serve the direct interest of protecting the rights, welfare, and safety of our older citizens, who so generously contribute their time, energy, and comfort to advance research to discover new treatments for this devastating disease.

摘要

第二届莱昂·塔尔年度研讨会（2009 年阿尔茨海默病会议；5:85-92）的已发表会议记录增加了该领域领导者之间的公开讨论，讨论的内容涉及制定一项国家战略，以加快发现预防阿尔茨海默病的干预措施。该报告中详细提出的建议“行动步骤”之一是建立一个国家神经退行性疾病机构审查委员会。这个新的伦理监督小组的目的是提高大规模多地点试验的效率。本文对这一建议进行了扩展，并简要考虑了两种潜在的组织模式。一个设计良好、高度合格且响应迅速的国家神经退行性疾病机构审查委员会将直接符合保护我们老年公民权利、福利和安全的利益，他们慷慨地贡献自己的时间、精力和舒适，以推进研究，为这种毁灭性疾病发现新的治疗方法。