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2010 年阿尔茨海默病事实和数据。

2010 Alzheimer's disease facts and figures.

出版信息

Alzheimers Dement. 2010 Mar;6(2):158-94. doi: 10.1016/j.jalz.2010.01.009.

Abstract

Alzheimer's disease (AD) is the seventh leading cause of all deaths in the United States and is virtually tied with the sixth leading cause of death-diabetes. AD is the fifth leading cause of death in Americans aged 65 and older. Although other major causes of death have been on the decrease, deaths because of AD have been rising dramatically. Between 2000 and 2006, heart disease deaths decreased 11.1%, stroke deaths decreased 18.2%, and prostate cancer-related deaths decreased 8.7%, whereas deaths because of AD increased 46.1%. Older African-Americans and Hispanics are more likely than older white Americans to have AD or other dementia. Current estimates are that African-Americans are about 2 times more likely, and Hispanics about 1.5 times more likely, than their white counterparts to have these conditions. However, the relationship of race and ethnicity to the development of AD and other dementias is complex and not fully understood. In 2009, nearly 11 million family and other unpaid caregivers provided an estimated 12.5 billion hours of care to persons with AD and other dementias; this care is valued at nearly $144 billion. Medicare payments for services to beneficiaries aged 65 years and older with AD and other dementias are three times higher than for beneficiaries without these conditions. Total payments for 2010 for health care and long-term care services for people aged 65 and older with AD and other dementias are expected to be $172 billion (not including the contributions of unpaid caregivers). An estimated 5.3 million Americans have AD; approximately 200,000 persons under age 65 with AD comprise the younger-onset AD population. Every 70 seconds, someone in America develops AD; by 2050 the time of every 70 seconds is expected to decrease to every 33 seconds. Over the coming decades, the baby boom population is projected to add 10 million people to these numbers. In 2050, the incidence of AD is expected to approach nearly a million people per year, with a total estimated prevalence of 11-16 million people. Dramatic increases in the numbers of "oldest old" (aged 85 years and older) across all racial and ethnic groups will also significantly affect the numbers of people living with AD. This report provides information to increase understanding of the public health effect of AD, including incidence and prevalence, mortality, costs of care, and effect on caregivers and society in general. This report also sets the stage for better understanding the relationship between race and ethnicity and the development of AD and other dementias.

摘要

阿尔茨海默病(AD)是美国第七大死亡原因,与第六大死亡原因糖尿病几乎持平。AD 是美国 65 岁及以上人群的第五大死亡原因。尽管其他主要死因一直在下降,但 AD 导致的死亡人数却在急剧上升。在 2000 年至 2006 年期间,心脏病死亡人数下降了 11.1%,中风死亡人数下降了 18.2%,前列腺癌相关死亡人数下降了 8.7%,而 AD 导致的死亡人数却增加了 46.1%。年长的非裔美国人和西班牙裔人比年长的白人美国人更容易患 AD 或其他痴呆症。目前的估计是,非裔美国人患这些疾病的可能性是白人的两倍,西班牙裔人患这些疾病的可能性是白人的 1.5 倍。然而,种族和民族与 AD 和其他痴呆症的发展之间的关系很复杂,目前还不完全清楚。2009 年,近 1100 万家庭成员和其他无薪护理人员为 AD 和其他痴呆症患者提供了约 125 亿小时的护理;这项护理的价值约为 1440 亿美元。医疗保险向 65 岁及以上患有 AD 和其他痴呆症的受益人的服务支付金额是没有这些疾病的受益人的三倍。预计 2010 年,65 岁及以上患有 AD 和其他痴呆症的人用于医疗保健和长期护理服务的总支出将达到 1720 亿美元(不包括无薪护理人员的贡献)。估计有 530 万美国人患有 AD;约有 20 万 65 岁以下的人患有早发性 AD,构成了早发性 AD 人群。在美国,每 70 秒就有一人患上 AD;到 2050 年,每 70 秒的时间预计将减少到每 33 秒。在未来几十年,婴儿潮一代的人口预计将使这些数字增加 1000 万人。到 2050 年,AD 的发病率预计将接近每年 100 万人,总估计患病率为 1100 万至 1600 万人。所有种族和族裔的“最年长”(85 岁及以上)人数的急剧增加也将显著影响患有 AD 的人数。本报告提供了有关 AD 的公共卫生影响的信息,包括发病率和患病率、死亡率、护理成本以及对护理人员和整个社会的影响。本报告还为更好地了解种族和族裔与 AD 和其他痴呆症的发展之间的关系奠定了基础。

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