Department of Otolaryngology Head and Neck Surgery, American University of Beirut, Beirut, Lebanon.
Otol Neurotol. 2010 Jun;31(4):567-73. doi: 10.1097/MAO.0b013e3181d8d3ad.
Review publications reporting radiation treatment of vestibular schwannomas (VS) and describe how data, patient characteristics, and study endpoints were reported.
PubMed search for English language articles on radiation treatment of VS published from January 2002 to July 2007.
Studies presenting outcomes were selected, yielding 56 articles (58 studies) in journals of neurosurgery (30), oncology (18), otolaryngology (6), and other (2).
DATA EXTRACTION/SYNTHESIS: Data included type of study, number of subjects, demographics, follow-up times, type of radiation, tumor size, tumor control definition, control rates, facial nerve function measure and outcome, type of hearing and vestibular testing and outcomes, and complications. Descriptive statistics were performed.
Studies (72.9%) were retrospective reviews with stated sample sizes ranging from 5 to 829. Gamma-knife (49.2%), linear accelerator (35.6%), and proton beam (6.8%) were used with various doses. Average follow-up was less than 5 years in 79.6% of studies, and 67.4% included patients at less than or equal to 1 year. Tumor size was reported as diameter (23.7%), volume (49.2%), both (11.9%), other (3.4%), or not reported (11.9%). Definition of tumor control varied: less than or equal to 2 mm growth (22.0%), no visible/measurable change (16.9%), required surgery (10.2%), other (17.0%), and not clearly specified (33.9%). Facial nerve outcome was reported as House-Brackmann (64.4%), normal/abnormal (11.9%), other (1.7%), or was not reported (22%).
The lack of uniform reporting criteria for tumor control, facial function and hearing preservation, and variability in follow-up times make it difficult to compare studies of radiation treatment for VS. We recommend consideration of reporting guidelines such as those used in otology for reporting VS resection results.
回顾报道前庭神经鞘瘤（VS）放射治疗的文献，并描述数据、患者特征和研究终点的报告方式。
在 PubMed 上搜索 2002 年 1 月至 2007 年 7 月发表的关于 VS 放射治疗的英文文献。
选择了有结局报道的研究，从神经外科（30 篇）、肿瘤学（18 篇）、耳鼻喉科（6 篇）和其他学科（2 篇）杂志中得出 56 篇文章（58 项研究）。
资料提取/综合：资料包括研究类型、研究对象数量、人口统计学资料、随访时间、放射类型、肿瘤大小、肿瘤控制定义、控制率、面神经功能测量和结局、听力和前庭测试类型及结局以及并发症。进行了描述性统计分析。
72.9%的研究为回顾性综述，有报道的样本量范围为 5 至 829 例。伽玛刀（49.2%）、线性加速器（35.6%）和质子束（6.8%）用于不同剂量。79.6%的研究平均随访时间不足 5 年，67.4%的研究纳入了随访时间不足或等于 1 年的患者。肿瘤大小的报道包括直径（23.7%）、体积（49.2%）、两者（11.9%）、其他（3.4%）或未报告（11.9%）。肿瘤控制的定义不同：生长小于或等于 2 毫米（22.0%）、无可见/可测量变化（16.9%）、需要手术（10.2%）、其他（17.0%）和未明确规定（33.9%）。面神经结局的报道包括 House-Brackmann（64.4%）、正常/异常（11.9%）、其他（1.7%）或未报告（22%）。
肿瘤控制、面神经功能和听力保护的报告标准缺乏一致性，随访时间的差异使得比较 VS 放射治疗的研究变得困难。我们建议考虑采用听力报告指南，如前庭神经鞘瘤切除术结果的报告指南。
