Waness Abdelkarim, Dawsari Ghuzayel Al, Al Jahdali Hamdan
Department of Internal Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
J Glob Infect Dis. 2009 Jul;1(2):131-8. doi: 10.4103/0974-777X.56256.
Invasive zygomycosis is a devastating fungal infection seen mostly in immune-compromised patients. We present a case of a 48-year old diabetic man, with aplastic anemia, who developed severe pulmonary mucormycosis that led to his rapid demise despite early diagnosis and treatment with liposomal amphotericin B. We also conducted an extensive review of the pathogenesis of invasive zygomycosis, its history, predisposing factors, clinical aspects, diagnostic modalities, treatment options, morbidity and mortality.
侵袭性接合菌病是一种主要见于免疫功能低下患者的毁灭性真菌感染。我们报告一例48岁患有再生障碍性贫血的糖尿病男性病例,该患者发生了严重的肺毛霉病,尽管早期诊断并接受了脂质体两性霉素B治疗,仍迅速死亡。我们还对侵袭性接合菌病的发病机制、病史、易感因素、临床特征、诊断方法、治疗选择、发病率和死亡率进行了广泛综述。