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前交叉韧带关节镜重建术后真菌感染导致的大量骨质流失

Massive bone loss from fungal infection after anterior cruciate ligament arthroscopic reconstruction.

作者信息

Muscolo D Luis, Carbo Lisandro, Aponte-Tinao Luis A, Ayerza Miguel A, Makino Arturo

机构信息

Institute of Orthopedics Carlos E. Ottolenghi, Italian Hospital of Buenos Aires, Potosí 4215, 1199, Buenos Aires, Argentina.

出版信息

Clin Orthop Relat Res. 2009 Sep;467(9):2420-5. doi: 10.1007/s11999-009-0714-0. Epub 2009 Feb 4.

Abstract

Although there are numerous reports of septic pyogenic arthritis after arthroscopic anterior cruciate ligament (ACL) reconstruction, there is limited information regarding the outcomes of fungal infection. We determined the outcomes of six patients with mycotic infection after regular ACL reconstruction. There were four males and two females with a mean age of 33 years. We determined the number of procedures performed, bone loss originating to control infection, and final reconstruction in these patients. An average of five arthroscopic lavage procedures had been performed at the referring centers. Fungal infection was diagnosed based on pathologic samples; five infections were the result of mucormycosis and one was Candida. After final débridement, the mean segmental bone loss was 12.8 cm. All patients were treated with intravenous antifungal coverage and cement spacers before final reconstruction. At final followup, all patients were free of clinical infection. Three had reconstruction with an allograft-prosthesis composite, two with hemicylindrical allografts, and one with an intercalary allograft arthrodesis. Despite the extremely unusual presentation of this complication, surgeons should be aware of potential and catastrophic consequences of this severe complication after ACL reconstruction.

摘要

尽管有大量关于关节镜下前交叉韧带(ACL)重建术后化脓性关节炎的报道,但关于真菌感染的预后信息有限。我们确定了6例常规ACL重建术后发生霉菌感染患者的预后情况。其中男性4例,女性2例,平均年龄33岁。我们确定了这些患者所进行的手术次数、为控制感染而出现的骨质流失情况以及最终的重建情况。在转诊中心平均进行了5次关节镜灌洗手术。根据病理样本诊断为真菌感染;5例感染为毛霉菌病,1例为念珠菌感染。在最终清创后,平均节段性骨质流失为12.8厘米。所有患者在最终重建前均接受了静脉抗真菌治疗并使用了骨水泥间隔物。在最终随访时,所有患者均无临床感染。3例采用同种异体移植物-假体复合物进行重建,2例采用半圆柱形同种异体移植物,1例采用节段间同种异体骨融合术。尽管这种并发症的表现极为罕见,但外科医生应意识到ACL重建术后这种严重并发症可能带来的潜在灾难性后果。

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