Schatzberg A F
Department of Psychiatry, Harvard Medical School, Boston, Mass.
J Clin Psychiatry. 1991 May;52 Suppl:14-20.
In this paper, the author reviews the dosing strategy for each major class of antidepressant drugs. The long-accepted strategy of moving from low to high dosages may need to be revised when the newer serotonergic agents are used to treat depressed patients. Evidence indicates that these drugs may be both better tolerated and more effective at lower dosages. Several studies in support of this hypothesis are reviewed. Possible dosing strategies of serotonergic agents, such as fluoxetine, in the treatment of obsessive compulsive disorder, obesity, and other nondepressive disorders, are also discussed.
在本文中，作者回顾了各类主要抗抑郁药物的给药策略。当使用新型血清素能药物治疗抑郁症患者时，长期以来被接受的从低剂量逐渐增加到高剂量的策略可能需要修订。有证据表明，这些药物在较低剂量时耐受性更好且更有效。本文回顾了多项支持这一假设的研究。还讨论了血清素能药物，如氟西汀，在治疗强迫症、肥胖症和其他非抑郁性疾病时可能的给药策略。
