Goodman W K, Charney D S
J Clin Psychiatry. 1985 Oct;46(10 Pt 2):6-24.
Tricyclic antidepressants, monoamine oxidase inhibitors, and antidepressants of atypical structure are used in a variety of psychiatric and nonpsychiatric disorders. The efficacy of antidepressant drugs in major depression, panic disorder, obsessive-compulsive disorder, peptic ulcer disease, enuresis, chronic pain, migraine, bulimia, and attention deficit disorder is briefly reviewed. The rationale that led to each of these therapeutic applications is examined, and the possible mechanism of action is discussed in light of recent advances in neurobiologic research. It is concluded that improved understanding of antidepressant drugs' mechanisms of action may help elucidate the etiology of these disorders and yield more effective treatments.
三环类抗抑郁药、单胺氧化酶抑制剂及非典型结构的抗抑郁药被用于多种精神疾病和非精神疾病。本文简要回顾了抗抑郁药在重度抑郁症、惊恐障碍、强迫症、消化性溃疡病、遗尿症、慢性疼痛、偏头痛、贪食症及注意力缺陷障碍中的疗效。探讨了促成每种治疗应用的基本原理，并根据神经生物学研究的最新进展讨论了可能的作用机制。得出的结论是，对抗抑郁药作用机制的进一步了解可能有助于阐明这些疾病的病因，并产生更有效的治疗方法。
