Zhou Cheng-Jun, Guo Jian-Qiang, Zhu Kong-Xi, Zhang Qing-Hui, Pan Cheng-Ran, Xu Wei-Hua, Wang Hong-Juan, Liu Bin
Department of Digestive Disease, The Second Hospital, Shandong University, #247 Bei-Yuan Street, Jinan, Shandong, People's Republic of China.
Diagn Cytopathol. 2011 Feb;39(2):105-9. doi: 10.1002/dc.21348.
To investigate the SOX9 expression and its effects on promoting invasion and metastasis in the primary gastric adenocarcinomas. One hundred and eighty six patients with primary gastric adenocarcinomas who underwent surgery between 2002 and 2006 were classified as low, intermediate, and high SOX9 expression groups by immunohistochemistry (IHC). Our IHC performance showed that SOX9 was lowly expressed in lower crypt of the normal epithelium adjacent to the tumor, and SOX9 expression was also observed in the intestinal metaplastic epithelium, but no SOX9 expression was detected in the surface epithelium. The stronger SOX9 expression was observed in the T3-T4 group than in the T1-T2 group, and there was a significant difference between the two groups (P < 0.0005). The SOX9 expression was correlated with the lymph node metastasis, and it showed significant between N0, N1, N2, and N3 groups (P < 0.0005). Similar to the lymph node metastasis classification, the SOX9 expression was also related to the tumor staging. From the stage Ia-Ib to stage II-IIIa and stage IIIb-IV, the SOX9 expression was elevated and the difference was significant (P < 0.0005). On the contrary, the SOX9 expression was not related to the histological classification (P > 0.05). Also the SOX9 expression showed no significance in patient age (P > 0.05). The SOX9 is overexpressed in the advanced stage of gastric carcinoma. SOX9 is related to the tumor progression though promoting invasion and metastasis, probably via enhancing the adhesion between the tumor cells and matrix or vessels which facilitates the tumor cells metastasis.
研究原发性胃腺癌中SOX9的表达及其对促进侵袭和转移的作用。对2002年至2006年间接受手术的186例原发性胃腺癌患者，通过免疫组织化学（IHC）分为SOX9低表达、中度表达和高表达组。我们的免疫组织化学结果显示，SOX9在肿瘤旁正常上皮的下隐窝中低表达，在肠化生上皮中也观察到SOX9表达，但在表面上皮中未检测到SOX9表达。T3 - T4组中SOX9表达高于T1 - T2组，两组间差异有统计学意义（P < 0.0005）。SOX9表达与淋巴结转移相关，在N0、N1、N2和N3组间差异有统计学意义（P < 0.0005）。与淋巴结转移分类相似，SOX9表达也与肿瘤分期相关。从Ia - Ib期到II - IIIa期以及IIIb - IV期，SOX9表达升高且差异有统计学意义（P < 0.0005）。相反，SOX9表达与组织学分类无关（P > 0.05）。在患者年龄方面，SOX9表达也无统计学意义（P > 0.05）。SOX9在胃癌晚期过度表达。SOX9可能通过增强肿瘤细胞与基质或血管之间的黏附促进侵袭和转移，从而与肿瘤进展相关。
