Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Int J Oral Maxillofac Surg. 2010 May;39(5):424-9. doi: 10.1016/j.ijom.2010.02.004. Epub 2010 Mar 29.
Alveolar reconstruction of bony defects in cleft lip and palate patients is a widely accepted treatment regimen for which multiple donor sites can be used. For 25 years, autogeneous bicortical mandibular symphyseal bone grafts have been used at the authors' centre. In cases in which the alveolar defect was too large to match the volume of the mandibular symphyseal bone transplant, beta-TCP granules were packed against the bone transplant to fill the defect completely. In a retrospective study, 18 patients, who were treated with mandibular symphyseal bone wrapped in beta-TCP granules, were compared with 29 patients, who were treated with mandibular symphyseal bone only. To assess alveolar height, occlusal radiographs were taken directly postoperatively and 1 year later. Mean alveolar bone loss was calculated and compared between groups using Student's t-test and linear regression analysis. No statistically significant difference in alveolar height was found between the two groups. It was concluded that mandibular symphyseal bone grafts enriched with beta-TCP granules can be used successfully in cases in which the alveolar cleft is too large to be grafted with mandibular symphyseal bone alone.
牙槽裂患者的骨缺损重建是一种广泛接受的治疗方案，可采用多种供体部位。25 年来，作者中心一直使用自体双皮质下颌联合骨移植。在牙槽骨缺损过大，无法匹配下颌联合骨移植体积的情况下，将β-TCP 颗粒填充在骨移植物上，以完全填补缺损。在一项回顾性研究中，将 18 名接受包裹β-TCP 颗粒的下颌联合骨治疗的患者与 29 名仅接受下颌联合骨治疗的患者进行了比较。为了评估牙槽骨高度，术后直接和 1 年后拍摄咬合片。使用 Student's t 检验和线性回归分析比较两组之间的平均牙槽骨丢失。两组之间的牙槽骨高度没有统计学上的显著差异。结论是，在用下颌联合骨单独移植无法修复的过大牙槽裂中，富含β-TCP 颗粒的下颌联合骨移植可以成功使用。
