Columbia University, Department of Chemistry, Havemeyer Hall, MC 3129, 3000 Broadway, New York, NY 10027, USA.
Curr Opin Chem Biol. 2010 Jun;14(3):347-61. doi: 10.1016/j.cbpa.2010.02.018. Epub 2010 Mar 18.
This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.
这篇综述探讨了利用特权支架通过构建化学文库来鉴定生物活性化合物的概念。我们希望实现三个主要目标:提供最全面的特权支架列表之一;通过四个选定的例子揭示特权支架文库合成的当前技术水平(希望激发新的甚至更具创造性的方法);并对如何识别和利用新的特权支架提出一些看法。