St. George's Vascular Institute, St George's Healthcare NHS Trust, London, United Kingdom.
J Vasc Surg. 2010 Jun;51(6):1329-38. doi: 10.1016/j.jvs.2009.10.131. Epub 2010 Mar 19.
This study was conducted to define the outcomes of treating aortic aneurysms involving the arch vessels with a hybrid approach using extra-anatomic reconstruction and endovascular repair with nonfenestrated stents.
A single-center review was done of arch aneurysm endovascular repairs during an 8-year period. Data were collected for patient demographics and aneurysm pathology. Any revascularization procedures performed were analyzed to detect differences between groups and through fitting a logistic regression model. The outcome measures were postoperative death, stroke, and paraplegia.
Between 2001 and 2009, 78 patients (65% men; mean age, 65 years) underwent endovascular repair of aortic arch aneurysms. Coverage of the left subclavian artery (LSA) was necessary in all patients to access an adequate proximal landing zone. An Ishimaru zone 0 proximal landing zone was present in 9 patients, 17 had zone 1, and 52 had zone 2. Fifty patients (64%) underwent elective endografting with an in-hospital mortality rate of 4%, and 28 patients (36%) underwent emergency procedures with a mortality rate of 14.3%. The LSA was revascularized in 31 elective (62%) and 4 emergency patients (14%). LSA revascularization was associated with significantly better outcomes for the combined measure of death, stroke, and paraplegia (odds ratio [OR], 15.6; 95% confidence interval [CI], 1.83-142; P = .012). Patients with an atherosclerotic aneurysm had worse outcomes than those with aortic dissection (OR, 5.52; 95% CI 1.26-24.4; P = .024), with dissections having preponderance toward emergency procedures (OR, 2.92; 95% CI, 1.12-7.58; P = .035).
Aneurysms involving the aortic arch vessels can be effectively treated by staged endovascular-surgical hybrid procedures with good outcomes that can be further improved through prior revascularization of the LSA.
本研究旨在定义使用解剖外重建和非开窗支架血管内修复联合治疗累及主动脉弓血管的主动脉瘤的结果。
对 8 年内行主动脉弓动脉瘤血管内修复术的患者进行单中心回顾。收集患者人口统计学和动脉瘤病理学数据。分析任何血运重建手术,以检测组间差异并通过拟合逻辑回归模型。观察指标为术后死亡、卒中和截瘫。
2001 年至 2009 年期间,78 例患者(65%为男性;平均年龄 65 岁)接受了主动脉弓动脉瘤的血管内修复。为了到达足够的近端着陆区,所有患者都需要覆盖左锁骨下动脉(LSA)。9 例患者存在 Ishimaru 0 区近端着陆区,17 例患者存在 1 区,52 例患者存在 2 区。50 例(64%)患者接受了择期血管内修复术,院内死亡率为 4%,28 例(36%)患者接受了急诊手术,死亡率为 14.3%。31 例(62%)择期和 4 例(14%)急诊患者进行了 LSA 血运重建。LSA 血运重建与死亡、卒中和截瘫的综合测量结果显著相关(比值比 [OR],15.6;95%置信区间 [CI],1.83-142;P =.012)。与主动脉夹层患者相比,动脉粥样硬化性动脉瘤患者的预后较差(OR,5.52;95% CI,1.26-24.4;P =.024),夹层患者更倾向于急诊手术(OR,2.92;95% CI,1.12-7.58;P =.035)。
通过分期血管内-手术杂交治疗累及主动脉弓血管的动脉瘤,可以获得良好的结果,通过预先进行 LSA 血运重建可以进一步改善结果。