胚胎鸡细胞产生环磷酸腺苷

Cyclic adenosine monophosphate production by embryonic chick cells.

作者信息

Robertson A, Grutsch J F, Gingle A R

出版信息

Science. 1978 Mar 3;199(4332):990-1. doi: 10.1126/science.203037.

DOI:10.1126/science.203037

PMID:203037

Abstract

Cells dissociated from 1-day-old chick embryos produce a pulse of cyclic adenosine monophosphate (cyclic AMP) when stimulated with cyclic AMP. There is a stimulus threshold concentration of about 10(-8) molar cyclic AMP and an upper limit, above which the response is suppressed, of about 6 X 10(-6) molar. The response occurs within 5 seconds of stimulation and corresponds to an average pulse size in the range of 10(7) molecules per cell.

摘要

从1日龄鸡胚中分离出的细胞在用环磷酸腺苷（cAMP）刺激时会产生一阵环磷酸腺苷脉冲。存在一个约10^(-8)摩尔的环磷酸腺苷刺激阈值浓度，以及一个上限，高于该上限响应会受到抑制，该上限约为6×10^(-6)摩尔。响应在刺激后5秒内发生，对应于每个细胞平均脉冲大小在10^7个分子的范围内。