Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Adv Drug Deliv Rev. 2011 Mar 18;63(3):131-5. doi: 10.1016/j.addr.2010.03.011. Epub 2010 Mar 18.
Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors.
增强型通透性和保留（EPR）效应是大分子和小颗粒在肿瘤中积累的基于生理学的主要机制。本期《高级药物传递评论》总结了多项基于 EPR 效应的药物设计和临床结果数据。在这篇评论中，简要讨论了 EPR 效应在蛋白质和肽类药物、大分子药物和载药长循环药物纳米载体向肿瘤内传递中的作用，以及最初的 EPR 效应介导含药物大分子系统在肿瘤中积累所带来的一些额外的药物传递机会。
