Mosseri Andrea, Sanchez-Uriel Leticia, Garcia-Peiro Jose I, Hornos Felipe, Hueso Jose L
Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Campus Río Ebro, Edificio I+D, C/Poeta Mariano Esquillor, s/n, 50018 Zaragoza, Spain.
Department of Chemical and Environmental Engineering, University of Zaragoza, Campus Río Ebro, C/María de Luna, 3, 50018 Zaragoza, Spain.
Int J Mol Sci. 2025 Jun 18;26(12):5850. doi: 10.3390/ijms26125850.
Stimuli-responsive silica nanoparticles have emerged as a promising platform for the targeted and controlled delivery of therapeutic agents in cancer therapy. These nanoparticles possess unique physicochemical properties that allow for the stimuli-triggered release of loaded cargos, such as drugs, enzymes, oligonucleotides, photosensitizers, and metals. The stimuli-responsive nature of these nanoparticles enables them to respond to specific internal and external signals within the tumor microenvironment, including pH, temperature, and redox potential, among others. This leads to the enhanced targeting of cancer cells and improved therapeutic efficacy while minimizing the off-target effects. This review highlights recent advances in the development and application of stimuli-responsive silica nanoparticles for the delivery of multiple active agents for cancer therapy. Overall, stimuli-responsive silica nanoparticles offer great potential for the development of more effective cancer therapies with improved selectivity and reduced side effects.
刺激响应性二氧化硅纳米颗粒已成为癌症治疗中用于治疗剂靶向和可控递送的一个有前景的平台。这些纳米颗粒具有独特的物理化学性质，能够实现负载货物（如药物、酶、寡核苷酸、光敏剂和金属）的刺激触发释放。这些纳米颗粒的刺激响应特性使其能够响应肿瘤微环境内的特定内部和外部信号，包括pH值、温度和氧化还原电位等。这导致癌细胞的靶向性增强、治疗效果改善，同时将脱靶效应降至最低。本综述重点介绍了刺激响应性二氧化硅纳米颗粒在开发和应用方面的最新进展，这些纳米颗粒用于递送多种活性剂以进行癌症治疗。总体而言，刺激响应性二氧化硅纳米颗粒在开发更有效、选择性更高且副作用更小的癌症治疗方法方面具有巨大潜力。
