Department of Psychiatry, Incheon St. Mary's Hospital, The Catholic University of Korea, #665, Bupyeongdong, Bupyeonggu, Incheon, 403-720, Republic of Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):674-80. doi: 10.1016/j.pnpbp.2010.03.011. Epub 2010 Mar 19.
We recorded event-related potentials (ERPs) in patients with schizophrenia before and after treatment with quetiapine, to investigate this drug's effects on cognitive function. Auditory and visual oddball stimulus discrimination paradigms were presented to patients with schizophrenia (N=20) before and after 3months' treatment with quetiapine. The 2-stimulus auditory oddball paradigm used a standard tone (1000Hz, 75dB, 80%) and a target tone (2000Hz, 75dB, 20%). The 2-stimulus visual oddball paradigm used a standard stimulus (small circle, 80%) and a target stimulus (large circle, 20%). Patients' severity of psychopathology was initially evaluated with the Positive and Negative Syndrome Scale (PANSS) and was likewise re-evaluated after treatment. After treatment with quetiapine, patients' P300 amplitudes increased over baseline for both tasks (auditory stimuli, P<0.01; visual stimuli, P<0.01) and their P300 latencies for both target stimuli decreased significantly (auditory stimuli, P<0.001; visual stimuli, P<0.01). Visual P300 amplitude was negatively correlated with the severity of positive symptoms at the Fz electrode before the treatment (r=-0.45, P<0.05). After treatment with quetiapine, there were no significant correlations between severity of positive or negative symptoms and visual P300 amplitudes for midline electrodes. These findings suggest that the reduced and delayed P300 may be a state marker for schizophrenia, which may in turn be modulated by positive symptoms, and also suggest that the amplitude and latency for both auditory and visual tasks may be decreased by quetiapine treatment. Based on these results, we suggest that the atypical antipsychotic quetiapine may improve some aspects of cognitive domains in patients with schizophrenia.
我们记录了精神分裂症患者在接受喹硫平治疗前后的事件相关电位（ERPs），以研究该药物对认知功能的影响。在接受喹硫平治疗 3 个月前后，我们向精神分裂症患者（N=20）呈现了听觉和视觉Oddball 刺激辨别范式。两刺激听觉 Oddball 范式使用标准音（1000Hz，75dB，80%）和目标音（2000Hz，75dB，20%）。两刺激视觉 Oddball 范式使用标准刺激（小圆圈，80%）和目标刺激（大圆圈，20%）。患者的精神病严重程度最初用阳性和阴性综合征量表（PANSS）进行评估，并在治疗后再次评估。接受喹硫平治疗后，患者在两项任务中的 P300 振幅均较基线增加（听觉刺激，P<0.01；视觉刺激，P<0.01），且两项任务中的 P300 潜伏期均显著缩短（听觉刺激，P<0.001；视觉刺激，P<0.01）。治疗前，Fz 电极处的阳性症状严重程度与视觉 P300 振幅呈负相关（r=-0.45，P<0.05）。接受喹硫平治疗后，中线电极处的阳性或阴性症状严重程度与视觉 P300 振幅之间无显著相关性。这些发现表明，减少和延迟的 P300 可能是精神分裂症的状态标志物，这可能反过来受到阳性症状的调节，也表明听觉和视觉任务的振幅和潜伏期可能会因喹硫平治疗而降低。基于这些结果，我们建议非典型抗精神病药喹硫平可能改善精神分裂症患者认知领域的某些方面。
