Stefánsson S B, Jónsdóttir T J
Department of Psychiatry, Landspítalinn, Kleppur, Reykjavík, Iceland.
Biol Psychiatry. 1996 Jul 1;40(1):19-27. doi: 10.1016/0006-3223(95)00351-7.
The aim of this study was to test predictions based on Grossberg's theories of overarousal in neural networks as related to schizophrenic symptomatology. We predicted that symptoms of blunted affect and volition would be associated with reduced P300 amplitude, while impaired attention and short-term memory and symptoms of disorganization would be associated with increased N200 and P300 latency. Event-related potentials, elicited by auditory stimuli, were recorded in 20 chronic schizophrenic men on neuroleptic medication and an age- and sex-matched control group of 20 normal volunteers. The amplitude and latency values of the N200 and P300 waves at the vertex (Cz) were compared with clinical ratings (the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms) and with neuropsychological test scores by means of Spearman rank correlation coefficient. The patients showed a reduced P300 amplitude and an increased N200 latency. No correlation was found between the P300 amplitude and the symptom scores. The N200 latency was negatively correlated with auditory digit span and positively correlated with high global scores for attentional impairment, alogia, and positive formal thought disorder. Our initial predictions are partly confirmed by the apparent association between increased N200 latency and symptoms of disorganization.
本研究的目的是检验基于格罗斯伯格神经网络过度唤醒理论与精神分裂症症状学相关的预测。我们预测情感迟钝和意志减退症状将与P300波幅降低有关，而注意力和短期记忆受损以及紊乱症状将与N200和P300潜伏期延长有关。由听觉刺激诱发的事件相关电位，在20名服用抗精神病药物的慢性精神分裂症男性患者以及20名年龄和性别匹配的正常志愿者对照组中进行记录。通过斯皮尔曼等级相关系数，将头顶（Cz）处N200和P300波的波幅和潜伏期值与临床评分（阳性症状评定量表和阴性症状评定量表）以及神经心理学测试分数进行比较。患者表现出P300波幅降低和N200潜伏期延长。未发现P300波幅与症状评分之间存在相关性。N200潜伏期与听觉数字广度呈负相关，与注意力损害、言语贫乏和阳性形式思维障碍的高总体评分呈正相关。N200潜伏期延长与紊乱症状之间的明显关联部分证实了我们最初的预测。
