Qiu Yao-qin, Tang Yun-xiang, Chan Raymond C K, Sun Xin-yang, He Jia
School of Nursing, Second Military Medical University, Shanghai, P.R. China; Department of Statistics, Faculty of Medical Services, Second Military Medical University, Shanghai, P.R. China.
Department of Medical Psychology, Faculty of psychology and mental healthy, Second Military Medical University, Shanghai, P.R. China.
PLoS One. 2014 Jun 16;9(6):e97794. doi: 10.1371/journal.pone.0097794. eCollection 2014.
Decreased P300 amplitude is one of the most consistent findings in patients with schizophrenia. However, whether prolonged P300 latency occurs in patients with schizophrenia, especially first-episode schizophrenia (FES) patients, remains controversial.
A meta-analyses of P300 aberration in FES patients and healthy control(HC) group was conducted. The meta-regression analysis was performed using a random effects model. The pooled standardized effect size (PSES) was calculated as the division of the difference between the means of the two groups by the common standard deviation.
A total of 569 FES patients and 747 HCs were included in this meta-analysis. P300 amplitude was significantly reduced (PSES = -0.83, 95% CI: -1.02-0.65, P = 0.00001) and P300 latency was delayed significantly in FES patients (PSES = -0.48, 95% CI: 0.14-0.81, P = 0.005). The meta-regression analysis showed that task difficulty was a source of heterogeneity.
The meta-analysis confirms that disrupted information processing is found in FES patients, which is manifested by smaller P300 amplitude and delayed P300 latency.
P300波幅降低是精神分裂症患者最一致的发现之一。然而，精神分裂症患者，尤其是首发精神分裂症（FES）患者是否存在P300潜伏期延长仍存在争议。
对FES患者和健康对照组（HC）的P300异常进行荟萃分析。采用随机效应模型进行荟萃回归分析。合并标准化效应量（PSES）计算为两组均值之差除以共同标准差。
本荟萃分析共纳入569例FES患者和747例HC。FES患者的P300波幅显著降低（PSES = -0.83，95%CI：-1.02 - 0.65，P = 0.00001），P300潜伏期显著延迟（PSES = -0.48，95%CI：0.14 - 0.81，P = 0.005）。荟萃回归分析表明任务难度是异质性的一个来源。
荟萃分析证实FES患者存在信息处理障碍，表现为P300波幅减小和P300潜伏期延迟。
