急性缺氧通过 ERK 通路促进 tau 的磷酸化。
Acute hypoxia promote the phosphorylation of tau via ERK pathway.
机构信息
Key Laboratory of Brain Function and Diseases, School of Life Science, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230027, Anhui, China.
Key Laboratory of Brain Function and Diseases, School of Life Science, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230027, Anhui, China.
出版信息
Neurosci Lett. 2010 May 3;474(3):173-177. doi: 10.1016/j.neulet.2010.03.037. Epub 2010 Mar 19.
Tau phosphorylation and hypoxia are both linked to the pathology of Alzheimer's disease. To find out the possible connection between hypoxia and tau phosphorylation, we performed this study to evaluate the level of phosphorylated tau under hypoxic or normal condition. We found in our study that hypoxia promoted the phosphorylation of tau protein via ERK pathway, which suggest hypoxia might be involved in the process of tau pathology.
tau 磷酸化和缺氧都与阿尔茨海默病的病理学有关。为了探究缺氧和 tau 磷酸化之间的可能联系，我们进行了这项研究，以评估在缺氧或正常条件下 tau 磷酸化的水平。我们的研究发现，缺氧通过 ERK 通路促进 tau 蛋白的磷酸化，这表明缺氧可能参与了 tau 病理过程。
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