Ozdinler P Hande
Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Brain Sci. 2024 Sep 27;14(10):978. doi: 10.3390/brainsci14100978.
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with progressive neurodegeneration, affecting both the cortical and the spinal component of the motor neuron circuitry in patients. The cellular and molecular basis of selective neuronal vulnerability is beginning to emerge. Yet, there are no effective cures for ALS, which affects more than 200,000 people worldwide each year. Recent studies highlight the importance of the glymphatic system and its proper function for the clearance of the cerebral spinal fluid, which is achieved mostly during the sleep period. Therefore, a potential link between problems with sleep and neurodegenerative diseases has been postulated. This paper discusses the present understanding of this potential correlation.
肌萎缩侧索硬化症（ALS）是一种伴有进行性神经退行性变的运动神经元疾病，会影响患者运动神经元回路的皮质和脊髓部分。选择性神经元易损性的细胞和分子基础正逐渐显现。然而，目前尚无针对ALS的有效治疗方法，该病每年在全球影响着超过20万人。最近的研究强调了类淋巴系统及其正常功能对于脑脊液清除的重要性，而这一过程主要在睡眠期间完成。因此，有人推测睡眠问题与神经退行性疾病之间可能存在联系。本文讨论了对这种潜在关联的当前认识。
