Sanderlin Ashley H, Hayden Kathleen M, Baker Laura D, Craft Suzanne
Department of Internal Medicine-Gerontology and Geriatric Medicine Wake Forest University School of Medicine Winston-Salem North Carolina USA.
Department of Social Sciences and Health Policy Wake Forest University School of Medicine Winston-Salem North Carolina USA.
Alzheimers Dement (N Y). 2022 Sep 14;8(1):e12343. doi: 10.1002/trc2.12343. eCollection 2022.
Sleep and diet are modifiable risk factors for Alzheimer's disease (AD) that may be salient areas for the development of preventive intervention strategies against dementia in people with mild cognitive impairment (MCI). Sleep disturbances account for up to 15% of the population attributable risk for AD. Diet influences sleep quality, such that diets high in sugars, fat, and processed food affect sleep quality and cognition in older adults. The combination of poor sleep and diet health may increase risk for dementia in people with MCI, yet it is unknown how intervening on diet may influence sleep health.
The MCI Sleep Study assesses longitudinal changes in objective and subjective measures of sleep between two investigational diet groups in the Brain Energy for Amyloid Transformation in Alzheimer's Disease study: the modified Mediterranean ketogenic diet (MMKD) and the American Heart Association diet. Objective sleep assessments include an in-home sleep study using the WatchPAT Central Plus (Itamar Medical, Ltd) at baseline and the end of the 4-month diet intervention. Subjective sleep questionnaires include the Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index. The MCI Sleep Study outcome measures include longitudinal change in cognitive performance, mood, behavior, and quality of life.
Study recruitment is currently ongoing. We hypothesize the low-carb MMKD diet to have a beneficial impact on sleep health in individuals with MCI. Pre- and post-diet changes in sleep metrics across diet groups will be examined using mixed effects analysis of variance models.
Early assessment of chronic sleep and diet behaviors may be vital in understanding when interventions are necessary and the lifestyle modifications that should accompany future AD prevention and therapy recommendations.
睡眠和饮食是阿尔茨海默病（AD）的可改变风险因素，可能是针对轻度认知障碍（MCI）患者制定痴呆症预防干预策略的重要领域。睡眠障碍占AD人群归因风险的15%。饮食会影响睡眠质量，高糖、高脂肪和加工食品的饮食会影响老年人的睡眠质量和认知。睡眠不佳和饮食健康状况不佳的组合可能会增加MCI患者患痴呆症的风险，但尚不清楚饮食干预如何影响睡眠健康。
MCI睡眠研究评估了阿尔茨海默病淀粉样蛋白转化脑能量研究中两个研究饮食组之间睡眠客观和主观测量的纵向变化：改良地中海生酮饮食（MMKD）和美国心脏协会饮食。客观睡眠评估包括在基线和4个月饮食干预结束时使用WatchPAT Central Plus（Itamar Medical，Ltd）进行的家庭睡眠研究。主观睡眠问卷包括爱泼华嗜睡量表和匹兹堡睡眠质量指数。MCI睡眠研究的结果指标包括认知表现、情绪、行为和生活质量的纵向变化。
目前正在进行研究招募。我们假设低碳水化合物MMKD饮食对MCI个体的睡眠健康有有益影响。将使用方差分析模型的混合效应来检查各饮食组睡眠指标在饮食前后的变化。
对慢性睡眠和饮食行为的早期评估对于理解何时需要干预以及未来AD预防和治疗建议应伴随的生活方式改变可能至关重要。
