Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou, Taiwan.
J Clin Anesth. 2010 Mar;22(2):110-4. doi: 10.1016/j.jclinane.2009.03.014.
To determine whether warmed (body temperature) ropivacaine increases the speed of onset of sensory block of epidural anesthesia.
Prospective, randomized, double-blind study.
University hospital.
180 ASA physical status I and II patients, aged 18 to 64 years, undergoing elective anal surgery.
Patients were randomly divided into 6 groups defined by ropivacaine temperature [room temperature (RT) or body temperature (BT)] and concentration (0.5%, 0.75%, or 1.0%).
Sensory block was evaluated by pinprick at the T10, T12, L3, and the perianal region (S4, S5) dermatomes. pH values and adverse events were also recorded.
There were no differences in baseline demographics, pH, or upper sensory level between groups. Mean onset time of T12 and L3 sensory block was significantly faster for each BT than RT ropivacaine concentration. Anal region (S4, S5) sensory block was significantly faster after BT 0.75% versus RT 0.75% ropivacaine.
Warmed ropivacaine shortens the onset of sensory block of epidural anesthesia.
确定加温（体温）罗哌卡因是否会加快硬膜外麻醉感觉阻滞的起效速度。
前瞻性、随机、双盲研究。
大学医院。
180 名 ASA 身体状况 I 和 II 级、年龄在 18 至 64 岁之间的择期肛门手术患者。
患者随机分为 6 组，按罗哌卡因温度[室温（RT）或体温（BT）]和浓度（0.5%、0.75%或 1.0%）定义。
通过刺痛评估 T10、T12、L3 和肛周区域（S4、S5）皮区的感觉阻滞。还记录了 pH 值和不良事件。
各组间基线人口统计学、pH 值或上感觉水平无差异。BT 罗哌卡因浓度的 T12 和 L3 感觉阻滞的平均起效时间明显快于 RT 罗哌卡因浓度。BT 0.75% 罗哌卡因的肛周区域（S4、S5）感觉阻滞明显快于 RT 0.75% 罗哌卡因。
加温罗哌卡因可缩短硬膜外麻醉感觉阻滞的起效时间。
