Lee C S, Smith N M, Kahn S N
Department of Obstetrics and Gynecology, St. Luke's Hospital, Bethlehem, Pennsylvania.
J Reprod Med. 1991 Mar;36(3):156-60.
Recent reports in the clinical laboratory literature have raised questions about the accuracy of different methods of measuring serum estradiol. To determine whether between-method variability was clinically significant, we used five different commercial radioimmunoassay methods to measure the concentration of estradiol in sera from nine patients undergoing induction of ovulation for gamete intrafallopian transfer. There were large differences between the estradiol concentrations measured in the same samples by the different methods. Furthermore, apparent changes in concentration that would be regarded as clinically significant may reflect nothing more than the imprecision of the assay. Physicians using serum estradiol measurements to support therapeutic decisions should be aware that an excessive reliance on those measurements may be misleading.
临床检验文献中最近的报告对不同的血清雌二醇测量方法的准确性提出了质疑。为了确定方法间差异是否具有临床意义，我们使用了五种不同的商业放射免疫测定方法，来测量九名接受配子输卵管内移植促排卵治疗患者血清中的雌二醇浓度。不同方法对同一样本测量的雌二醇浓度存在很大差异。此外，被认为具有临床意义的浓度明显变化，可能仅仅反映了检测方法的不精确性。使用血清雌二醇测量结果来支持治疗决策的医生应该意识到，过度依赖这些测量结果可能会产生误导。
