Herrmann J, Heinen E, Rusche J I, Ströcker I
Nuklearmedizin. 1982 Oct;21(5):186-91.
In order to check whether the serum free T4 as obtained with commercially available kits can substitute for total T4 measurements in the routine diagnosis of thyroid disorders, serum FT4 was simultaneously assayed using 5 different methods (Amerlex; GammaCoat; Immo-Phase; LiquiSol; T4/TBG) in 152 subjects. Overt hyper- and hypothyroidism were readily distinguished from euthyroidism with each method. Discrepant FT4 results, however, were obtained with these assays in clinically euthyroid subjects exhibiting various extrathyroidal disorders (TBG-deficiency or -excess, late pregnancy, serious illness, T4 administration). Since it is as yet impossible to decide which of the commercial kits will yield methodologically and physiologically reliable results, a substitution of total T4 measurements by FT4 cannot yet be recommended in the laboratory diagnosis of thyroid disease.
为了检验市售试剂盒所测血清游离T4是否能在甲状腺疾病的常规诊断中替代总T4测量，我们使用5种不同方法（Amerlex；GammaCoat；Immo-Phase；LiquiSol；T4/TBG）对152名受试者同时检测血清FT4。每种方法都能轻易区分明显的甲状腺功能亢进和减退与甲状腺功能正常状态。然而，在患有各种甲状腺外疾病（TBG缺乏或过量、妊娠晚期、重病、服用T4）的临床甲状腺功能正常受试者中，这些检测方法得到的FT4结果存在差异。由于目前尚无法确定哪种市售试剂盒能产生方法学和生理学上可靠的结果，因此在甲状腺疾病的实验室诊断中，尚不能推荐用FT4替代总T4测量。
