Abbasi Seyed Hesameddin, Boroumand Mohammad Ali
National Iranian Oil Company Central Hospital, Tehran, Iran.
Open Cardiovasc Med J. 2010 Feb 23;4:38-44. doi: 10.2174/1874192401004020038.
Inflammatory biomarkers play a pivotal role in atherosclerotic lesions. The plasma levels of these markers are predictive of adverse outcomes such as myocardial infarction and cardiovascular death. The immune system is involved at all stages of atherogenesis via activation of monocytes/macrophages and T lymphocytes. Circulating proinflammatory cytokines and chemokines produced by these cells interact with specific receptors on various cells and activate specific signaling pathways, leading to inflammation-induced atherosclerotic lesions. Recent studies have focused on predictive value of inflammatory biomarkers such as C-reactive protein and interleukin-6. These biomarkers were shown to be associated with poor quality of life and predictive of adverse events in coronary atherosclerosis and left ventricular dysfunction. Vascular predictive value of other numerous inflammatory markers is being investigated. We herein analyze the role of several mediators of inflammation, affecting vascular functions and leading toward atherosclerotic lesions.
炎症生物标志物在动脉粥样硬化病变中起关键作用。这些标志物的血浆水平可预测心肌梗死和心血管死亡等不良后果。免疫系统通过单核细胞/巨噬细胞和T淋巴细胞的激活参与动脉粥样硬化发生的各个阶段。这些细胞产生的循环促炎细胞因子和趋化因子与各种细胞上的特定受体相互作用，激活特定信号通路，导致炎症诱导的动脉粥样硬化病变。最近的研究集中在C反应蛋白和白细胞介素-6等炎症生物标志物的预测价值上。这些生物标志物与生活质量差相关，并可预测冠状动脉粥样硬化和左心室功能障碍中的不良事件。其他多种炎症标志物的血管预测价值正在研究中。我们在此分析几种炎症介质的作用，这些介质影响血管功能并导致动脉粥样硬化病变。
